Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties

نویسندگان

  • Julio G. Palharini
  • Aline C. Richter
  • Mariana F. Silva
  • Flavia B. Ferreira
  • Carlos P. Pirovani
  • Karinne S. C. Naves
  • Vivian A. Goulart
  • Tiago W. P. Mineo
  • Marcelo J. B. Silva
  • Fernanda M. Santiago
چکیده

Eutirucallin is a lectin isolated from the latex of Euphorbia tirucalli, a plant known for its medical properties. The present study explores various characteristics of Eutirucallin including stability, cytotoxicity against tumor cells, antimicrobial and antiparasitic activities. Eutirucallin was stable from 2 to 40 days at 4°C, maintained hemagglutinating activity within a restricted range, and showed optimal activity at pH 7.0-8.0. Eutirucallin presented antiproliferative activity for HeLa, PC3, MDA-MB-231, and MCF-7 tumor cells but was not cytotoxic for non-tumorigenic cells such as macrophages and fibroblasts. Eutirucallin inhibited the Ehrlich ascites carcinoma in vivo and it was also observed that Eutirucallin inhibited 62.5% of Escherichia coli growth. Also, Eutirucallin showed to be effective when tested directly against Toxoplasma gondii infection in vitro. Therefore, this study sheds perspectives for pharmacological applications of Eutirucallin.

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عنوان ژورنال:

دوره 7  شماره 

صفحات  -

تاریخ انتشار 2017